I recently created an adwords campaign and I'm not getting any clickthroughs. The site is http://www.lchromatography.com. The keywords for this site are not searched for much because it's a very niche market. I've been targeting very specific keywords to make sure I don't pay for useless clicks. I have tried different ad text with no improvement.

So now I'm faced with the choice between targeting keywords that are extremely focused and relevant to the site but get no clicks, or paying a lot of $$ for clicks on more often clicked but very general keywords.

I'm going to tinker with it for a little while longer, but I think my money might be better spent with an ad on an industry-related website with high traffic. If anyone has any ideas on how to improve my ctr, I'd like to hear them.

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I would do more keyword research to find out who would be interested this.
Your site is indeed a very niche market. If you go after general keywords, you will get clicks that people are not interested in.

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Think also that if it is that specialist are you going to get a lot of people scanning the web for it anyway? I personally would suggest you keep your focused words and do not make them too general.

Think laterally and think if their are any other "specific" keywords that users/buyers of your service or product might use, that way by increasing your "specific" keywords you then capture more of that "small amount" of people who are searching for your product or service.

Also, if the more general keywords have high bids, you may want to look at other keywords with low traffic that others may not really think of. This is easier for high traffic search terms such as web hosting. You could target terms such as mysql host or php host or something like that. I've found that finding keywords like that really helped my Adwords campaigns.

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Yes thats a good idea also. Quite often you can get better hits with those words. It is definitely an art form. I think probably some people get good resutls with it and others probably don't.

I am bidding on a tough area and have had mixed results I think there are probably many different pathways to success and many different formula that actually work.

I wrote a free PPC report. it has about 10 - 15 pages of good seo tips.
http://www.seobook.com/archives/000376.shtml

also if you dont mind shelling out a few bucks andrew goodman
http://www.page-zero.com/products_asroi.asp
and perry marshall are good stuff.
http://www.perrymarshall.com/google/

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